Chen Chun-Lin
Laboratory
Department of Biological Sciences
National Sun Yat-sen University
1. Chih-Ling Chung, Chun-Lin Chen (2024, Feb). Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling. European Journal of Pharmacology. 2024 Apr 15;969:176421.. 本人為通訊作者.
2. Shun-Ban Tai, Huang Chih-yin, Chih-Ling Chung, Ping-Jyun Sung, and Chun-Lin Chen (2023, Dec). Prodigiosin inhibits Transforming growth factor β signaling by interfering receptor recycling and subcellular translocation in epithelial cells. Mol Pharmacol. 2024 Mar 14;105(4):286-300. 本人為通訊
3. Yang JL, Lin WL, Tai SB, Ciou YS, Chung CL, Chen JJ, Liu PF, Lin MW, Chen CL. Suppression of TGFβ-Induced Interleukin-6 Secretion by Sinulariolide from Soft Corals through Attenuation of the p38-NF-kB Pathway in Carcinoma Cells. Int J Mol Sci. 2023 Jul 19;24(14):11656. doi: 10.3390/ijms241411656. PMID: 37511415; PMCID: PMC10380600.
4. Chang YF, Wang HH, Shu CW, Tsai WL, Lee CH, Chen CL, Liu PF. TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer. Curr Issues Mol Biol. 2023 May 24;45(6):4529-4543. doi: 10.3390/cimb45060287. PMID: 37367036; PMCID: PMC10297151.
5. Tseng CC, Hung CC, Shu CW, Lee CH, Chen CF, Kuo MS, Kao YY, Chen CL, Ger LP, Liu PF. The Clinical and Biological Effects of Receptor Expression-Enhancing Protein 6 in Tongue Squamous Cell Carcinoma. Biomedicines. 2023 Apr 25;11(5):1270. doi: 10.3390/biomedicines11051270. PMID: 37238941; PMCID: PMC10215315.
6. Jen-Lung Chen, Yun-Shen Tai, Hsin-Yi Tsai, Chia-Yuan Hsieh, Chun-Lin Chen, Chung-Jung Liu, Deng-Chyang Wu, Yaw-Bin Huang *, Ming-Wei Lin *Betulinic acid inhibits the stemness of gastric cancer cells by regulating the GRP78-TGF-b1 signaling pathway and macrophage polarization. Molecules. 2023 Feb 11;28(4):1725. doi: 10.3390/molecules28041725. PMID: 36838713; PMCID: PMC9964887..
7. Lee, C.-H.; Tsai, H.-Y.; Chen, C.-L.; Chen, J.-L.; Lu, C.-C.; Fang, Y.-P.; Wu, D.-C.; Huang, Y.-B.; Lin, M.-W. Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation. Biomedicines 2022, 10, 1350
8. Shih, S.-P.; Lu, M.-C.; El-Shazly, M.; Lin, Y.-H.; Chen, C.-L.*; Yu, S.S.-F.; Liu, Y.-C. The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity. Life 2022, 12, 687.
9. Jadhao, M.; Chen, C.-L.; Liu, W.; Deshmukh, D.; Liao, W.-T.; Chen, J.Y.-F.; Urade, R.; Tsai, E.-M.; Hsu, S.-K.; Wang, L.-F.; et al. Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells. Biomedicines 2022, 10, 417.
10. Wang, K.-C., Lu, M.-C., Hsu, K.-C., El-Shazly, M., Shih, S.-P., Lien, S.-T., Kuo, F.-W., Yang, S.-C., Chen, C.-L.*, Yang, Yu-Chen S.-H. The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, is Mediated through ROS Induced Inhibition of HSP-90. Molecules. 2021 Nov 21;26(22):7037.
11. Tseng, Y.-K,. Chen, C.-F,. Shu, CW.-,. Lee, C.-H,. Chou, Y.-T,. Li, Y.-J,. Liou, H.-H,. Cheng, J.-T,. Chen, C.-L,. Ger, L.-P,. Liu, P.-F. SQSTM1 regulation by EGFR in malignancy and tumor progression of oral squamous cell carcinoma. International Journal of Molecular Sciences. 2021 Nov 12;22(22):12226.
12. Tsai, K.-J., Tsai, H.-Y., Tsai, C.-C., Chen, T.-Y., Hsieh, T.-H., Chen, C.-L., Mbuyisa, Lulekiwe., Huang , Y.-B., Lin, M.-W. Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity Through the Nrf2/ Cripto1 Signaling Pathway. 2021 Molecules. 2021 Oct 26;26(21):6452.
13. Huang, C.-Y., Yang, J.-L., Chen, J.-J., Tai, S.-B., Yeh, Y.-H., Liu, P.-F., Lin, M.-W., Chung, C.-L., Chen, Chen, C.-L.* Fluoroquinolones Suppress TGF-β and PMA-Induced MMP-9 Production in Cancer Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment. International Journal of Molecular Sciences. 2021 Oct 27;22(21):11602.
14. Wang, I.-C., Chen, L.-C., Chang, T.-H., Chen, C.-L,. Chen, J.-J. New Coumarin and Bioactive Constituents of Chionanthus retusus. Chem Nat Compd 57, 835–839 (2021).
15. Liu, P.-F,. Shu, C.-W,. Lee, C.-H,. Sie H.-C, Liou, H.-H,. Cheng, J.-T,. Ger, L.-P,. Chen, C.-L,. Chen, C.-C,. Chen, C.-F. Clinical Significance and the Role of Guanylate-Binding Protein 5 in Oral Squamous Cell Carcinoma. Cancers (Basel). 2021 Aug 11;13(16):4043.
16. Wu, F.-S., Hung, C.-J., Lin, C.-L., Chen, C.-L,. Chen, J.-J. . A New Benzophenone and Bioactive Constituents of Hypericum nokoense. Chem Nat Compd 57, 645–649 (2021).
17. Chen, C.-L., Huang, F. W., Huang, S. S., Huang, J. S., (2021) IGFBP-3 and TGF-β inhibit growth in epithelial cells by stimulating type V TGF-β
receptor (TβR-V)-mediated tumor suppressor signaling. FASEB BioAdvances. 2021 Jun 16;3(9):709-729. (第一作者)
18. Huang, S.-F., Wang, Y.-L., Chen, J.-J., Huang, Y.-B., Tai, S.-B., Chung, C.-L., and Chen, C.-L.*. (2021) Garcimultiflorone K from Garcinia multiflora attenuates hepatocellular carcinoma metastasis by suppressing Transforming growth factor-β signaling. Phytomedicine. 84, 153502 Link
19. Huang, C.-Y., Chung, C.-L., Hu, T.-H., Chen, J.-J., Liu, P.-F., and Chen, C.-L.*. (2021) Recent progress in TGF-β inhibitors for cancer therapy. Biomedicine & Pharmacotherapy. 134, 111046 Link
20. Wu, M. J., Vinit, S., Chen, C.-L., and Lee, K. Z. (2020) 5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion. Neurorehabilitation and Neural Repair. 34, 333-343 Link
21. Wu, F.-S., Hung, C.-J., Lin, C.-L., Chang, T.-H., Chen, C.-L., Sung, P.-J., Cheng, M.-J., Huang, H.-Y., and Chen, J.-J. (2020) New Norneolignan and Bioactive Constituents of Clitoria ternatea. Chemistry of Natural Compounds. 56, 1000-1004 Link
22. Liu, P. F., Chen, C. F., Shu, C. W., Chang, H. M., Lee, C. H., Liou, H. H., Ger, L. P., Chen, C.-L., and Kang, B. H. (2020) UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma. Diagnostics (Basel). 2020 Sep; 10(9): 674. Link
23. Huang, C.-M., Sung, P.-J., Kuo, Y.-H., Chang, T.-H., Chen, C.-L., Cheng, M.-J., and Chen, J.-J. (2020) A New Dihydroagarofuranoid Sesquiterpene and Cytotoxic Constituents of Microtropis fokienensis. Chemistry of Natural Compounds. 56, 440-444 Link
24. Hsiao, J.-W., Chen, C.-L., Lin, C.-L., Chang, T.-H., Chen, C.-L., Sung, P.-J., Cheng, M.-J., Hung, C.-J., and Chen, J.-J. (2020) A New Sesquiterpenoid and Bioactive Constituents of Curcuma zedoaria. Chemistry of Natural Compounds. 56, 1076-1080 Link
25. Chou, C. H., Wu, C. Y., Chen, C.-L., Zhou, J. Q., Kao, Y. C., Chen, H. Y., and Lin, P. C. (2020) In vivo monitoring of carbonic anhydrase expression during the growth of larval zebrafish: a new environment-sensitive fluorophore for responsive turn-on fluorescence. Chemical Communications (Camb) 56, 11307-11310 Link
26. Huang, H.-C., Chen, L.-C., Chang, T.-H., Zhu, T.-F., Chen, C.-L., Cheng, M.-J., and Chen, J.-J. (2019) A New Lignanamide Derivative and Bioactive Constituents of Lycium chinense. Chemistry of Natural Compounds. 55, 1002-1006 Link
27. Chung, C.-L., Tai, S.-B., Hu, T.-H., Chen, J.-J., and Chen, C.-L.*. Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling (2019) International Journal of Molecular Sciences. 2019 Aug; 20(16): 3913. Link
28. Chiou, H-Y., Lin, M.-W., Chen, C.-L., Lin, M.-H. (2019) Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System. International Journal of Molecular Sciences. 2019, 20(7), 1584 Link
29. Wu, P.-C., Hsu, W.-L., Chen, C.-L., Lam, C.-F., Huang, Y.-B., Huang, C.-C., Lin, M.-H., Lin, M.-W. (2018) Morphine Induces Fibroblast Activation through Up-regulation of Connexin 43 Expression: Implication of Fibrosis in Wound Healing. International Journal of Medical Science. 2018; 15(9):875-882. Link
30. Wang, S.-L., Liao, H.-R., Cheng, M.-J., Shu, C.-W., Chen, C.-L., Chung, M.-I., Chen, J.-J. (2018) Four New 2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibitory Activities on Neutrophil Pro-inflammatory Responses. Planta Medica. Link
31. Chung, C.-L., Wang, S.-W., Kao, Y.-C., Martin, R., Knölker, H.-J., Shiao, M.-S., and Chen, C.-L.*. (2018) Pentabromopseudilin, a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation. Journal of Enzyme Inhibition and Medicinal Chemistry. 33(1):920-935 Link
32. Chung, C.-L., Wang, S.-W., Sun, W.-C., Shu, C.-W., Kao, Y.-C., Shiao, M.-S., and Chen, C.-L.*., (2018) Sorafenib suppresses TGF-β responses by inducing caveolae/lipid raft–mediated internalization/degradation of cell-surface type II TGF-β receptors: implications in development of effective adjunctive therapy for hepatocellular carcinoma. Biochemical Pharmacology. 154 (2018) 39-53 Link
33. Cheng, L.-Y., Chen, C.-L., Kuo, Y.-H., Chang, T.-H., Lin, I.-W., Wang, S.-Y., Chung, M.-I., and Chen, J.-J. (2018) Polyprenylated Polycyclic Acylphloroglucinol: Angiogenesis Inhibitor from Garcinia multiflora. Bioorganic & Medicinal Chemistry Letters. 28 (2018) 1860–1863 Link
34. Chung, Y.-H., Huang, Y.-H., Chu, T.-H., Chen, C.-L., Lin, P.-R., Huang, S.-C., Wu, D.-C., Huang, C.-C., Hu, T.-H., Kao, Y.-H., and Tai, M.-H. (2018) BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling. Laboratory Investigation. Link
35. Chung, C.-L., Wang, S.-W., Martin, R., Knölker, H.-J., Kao, Y.-C., Lin, M.-H., Chen, J.-J., Huang, Y.-B., Wu, D.-C., and Chen, C.-L.*. (2018) Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells. Chembiochem. 2018 Apr 16;19(8):851-864.
36. Chen, H.-M., Wu, C.-Y., Chen, J.-J., Wu, D.-C., Liu, M.-Y., Huang, Y.-B., Huang, H.-T., Sun, W.-C., Shu, C.-W., Chen, C.-L.*., (2017) Mechanical Strain Enhances TGF-β Responsiveness by Altering TGF-β Receptor Partitioning Between Submembrane Microdomains in Vascular Smooth Muscle Cells. Journal of Biomaterials and Tissue Engineering. 7, 1028–1037. Link
37. Song, Y.-C., Wu, B.-J., Chiu, C.-C., Chen, C.-L., Zhou, J.-Q., Liang, S.-R., Duh, C.-Y., Sung, P.-J., Wen, Z.-H., and Wu, C.-Y., (2017) Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish. International Journal of Molecular Sciences. 2017, 18(8), 1696 Link
38. Huang, S.-S., Liu, I.-H., Chen, C.-L., Chang, J.-M., Johnson, F. E., Huang, J.-S., (2017) 7-Dehydrocholesterol (7-DHC), But Not Cholesterol, Causes Suppression of Canonical TGF-beta Signaling and Is Likely Involved in the Development of Atherosclerotic Cardiovascular Disease (ASCVD). Journal of Cellular Biochemistry. 2017;118(6):1387-400. Link
39. Chen, C.-L.*, Yang, P.-H., Kao, Y.-C., Chen, P.-Y., Chung, C.-L., Wang, S.-W. (2017) Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Scientific Reports. (SCI 5.228, Q1 7/63 MULTIDISPLINARY SCIENCES) Link (第一作者, 通訊作者)
40. Lin, C.-C., Lai, S.-R., Shao, Y.-H., Chen, C.-L., Lee, K.-Z. (2017) The therapeutic effectiveness of delayed fetal spinal cord tissue transplantation on respiratory function following mid-cervical spinal cord injury. Neurotherapeutics. Link (SCI 4.676, Q1 30/255 Pharmacology & Pharmacy)
41. Chen, J.-J., Wang, S.-W., Chen, C.-L., Kuo, Y.-H., Cheng, M.-J., Chang, T.-H., Sung, P.-J., Kuo, W.-L., Lim, Y.-P. (2017) A New Amide and Antioxidant Constituents from Piper taiwanense. Chemistry of Natural Compounds. Link (SCI 0.473, Q4 57/59 Chemistry & Medicinal)
42. Chen, C.-L.*, Wu, D.-C., Liu, M.-Y., Lin, M.-W., Huang, H.-T., Huang, Y.-B., Kao, Y.-C., Yang, P.-H., (2017) Cholest-4-en-3-one Attenuates TGF-β Responsiveness by Inducing TGF-β Receptors Degradation in Mv1Lu Cells and Colorectal Adenocarcinoma cells. Journal of Receptors and Signal Transduction. 2017 Apr;37(2):189-199. Link (第一作者, 通訊作者)
43. Chen, C.-L.*, Kao, Y.-C., Yang, P.-H., Sung, P.-J., Wen, J.-H., Chen, J.-J., Chen, P.-Y., (2016) A Small Dibromotyrosine Derivative Purified From Pseudoceratina Sp. Suppresses TGF-β Responsiveness by Inhibiting TGF-β Type I Receptor Serine/Threonine Kinase Activity. Journal Cellular Biochemistry. 2016 Dec;117(12):2800-2814. Link (第一作者, 通訊作者)
44. Chen, C.-L.*, Chen, C.-Y., Chen, Y.-P., Huang, Y.-B., Lin, M.-W., Wu, D.-C., Huang, H.-T., Liu, M.-Y., Chang, H.-W., Kao, Y.-C., Yang, P.-H.
Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells. Journal of Biomedical Science. (2016) 23:30 Link (第一作者, 通訊作者)
45. Chen, J.-J., Tsai, T.-H., Liao, H.-R., Chen, L.-C., Kuo, Y.-H., Sung, P.-J., Chen, C.-L., Wei, C.-S. (2016) New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria. Molecules. 2016, 21, 1385. Link
46. Lin M-W., Huang Y-B., Chen C-L., Wu P-C., Chou C-Y., Wu P-C., Hung S-Y. (2016) A formulation study of 5-aminolevulinic encapsulated in DPPC liposomes in melanoma treatment. Int. J. Med. Sci. 2016;doi:10.7150/ijms.15411 Link
47. Liu, C.-J., Kuo, F.-C., Wang, C.-L., Kuo, C.-H., Wang, S.-W., Chen, C.-Y., Huang, Y.-B., Cheng, K.-H., Yokoyama, K.K., Chen, C.-L., Lu, C.-Y., Wu, D.-C. (2016) Suppression of IL8-Src Signaling Axis by 17β-Estradiol Inhibits Human Mesenchymal Stem Cells-Mediated Gastric Cancer Invasion. Journal of Cellular and Molecular Medicine. Link (SCI, Q1 24/123 Medicine, Research & Experimental).
48. Huang, S.-S., Chen, C.-L., Huang, F.-W., Hou, W.-H., Huang, J.-S., (2015, Nov) DMSO Enhances TGF-β Activity by Recruiting the Type II TGF-β Receptor from Intracellular Vesicles to the Plasma Membrane. Journal of Cellular Biochemistry. DOI:10.1002/jcb.25448. Link
49. Li, R.-F., Wu, T.-Y., Mou, Y.-Z., Wang, Y.-S., Chen, C.-L., and Wu, C.-Y., (2015) Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development. Journal of Biomedical Science. 2015, 22:104 DOI:10.1186/s12929-015-0209-0. Link
50. Chen, C.-L.*, Chen, Y.-P., Lin, M.-W., Huang, Y.-B., Chang, F.-R., Duh, T.-H., Wu, D.-C., Wu, W.-C., Kao, Y.-C., Yang, P.-H., (2015, Oct) Euphol from Euphorbia tirucalli negatively modulates TGF-β responsiveness via TGF-β receptor segregation inside membrane rafts. PLOS ONE. DOI: 10.1371/journal.pone.0140249. Link (第一作者, 通訊作者)
51. Huang, I.-F., Lin, I.-C., Liu, P.-F., Cheng, M.-F., Liu, Y.-C., Hsieh, Y.-D., Chen, J.-J., Chen, C.-L., Chang, H.-W., Shu, C.-W., (2015, Oct) Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-beta signaling. BMC Microbiology. 2015;15:203. DOI:10.1186/s12866-015-0546-x. Link
52. Huang, S.-S., Chen, C.-L., Huang, F.-W., Johnson, F.-E., Huang, J.-S., (2015, Sep) Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains. Journal of Cellular Biochemistry. DOI: 10.1002/jcb.25389. Link
53. Fu, Y.-S., Kuo, S.-Y., Lin, H.-Y., Chen, C.-L., Huang, S.-Y., Wen, Z.-H., Lee, K.-Z., Huang, H.-T. Pretreatment with Evans blue, a stimulator of BKCa channels, inhibits compound 48/80‑induced shock, systemic inflammation, and mast cell degranulation in the rat. Vol. 143, No.6, 2015. DOI 10.1007/s00418-015-1332-4. (IF: 3.05) (SCI, 1/10 Microscopy). Link
54. Lin, M.-W., Huang, Y.-B., Liu, M.-Y., Chen, C.-L.*, Composite of Decellular Adipose Tissue with Chitosan-based Scaffold for Tissue Engineering with Adipose-derived Stem Cells. Journal of Biomaterials and Tissue Engineering, Vol. 5, 56–63, 2015. (IF: 2.1) (SCI, 16/21 CELL & TISSUE ENGINEERING) Link (通訊作者)
55. Wu, B.-J., Chiu, C.-C., Chen,C.-L., Wang,W.-D., Wang, J.-H., Wen, Z.-H., Liu, W., and Wu, C.-Y., (2014) Nuclear receptor subfamily 2 group f member 1a (nr2f1a) is required for vascular development in zebrafish. Plos One, Aug 26;9(8):e105939. Link (第一作者)
56. Wu, C-Y., Wu, D-C., Lin, M-W., Huang, H-T., Huang, Y-B., Chen, C.-L.*. (2014, May). The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. Br J Pharmacol. 2014 Dec;171(24):5541-54. (IF: 4.99) (SCI,21/256 PHARMACOLOGY & PHARMACY). Link (通訊作者)
57. Chen, C.-L., Liu, H., Guan, X., (2013) Changes in microRNA expression profile in hippocampus during the acquisition and extinction of cocaine-induced conditioned place preference in rats. Journal of Biomedical Science, 20;20:96. (IF:2.46). (第一作者)
58. Chen, C.-L., Iijima, M., (2012) Myosin I: A new pip3 effector in chemotaxis and phagocytosis. Communicative & Integrative Biology, 5(3): 1–3. (第一作者)
59. Chen, C.-L., Wang, Y., Sesaki, H., Iijima, M., (2012) PtdIns(3,4,5)P3-regulated Membrane Recruitment of Myosin I Promotes Actin Assembly in Chemotaxis. Science Signaling, 5, ra10. (IF:7.8). (第一作者)
60. Wang, Y., Chen, C.-L., Iijima, M., (2011) Signaling mechanisms for chemotaxis. Development growth and Differentiation 53(4):495-502 (IF:2.28)
61. Zhu, J.-H., Chen, C.-L., Flavahan, S., Harr, J., Su, B., Flavahan, NA., (2011) Cyclic stretch stimulates vascular smooth muscle cell alignment by Redox-dependent activation of Notch3. Am J Physiol Heart Circ Physiol., 300(5):H1770-H1780 (IF:4.109)
62. Guan, X., Wang, L., Chen, C.-L., Guan, Y., Li, S., (2010) Roles of two subtypes of corticotrophin-releasing factor (CRF) receptor in the corticostriatal long-term potentiation under cocaine withdrawal condition. J Neurochem., 115(3):795-803 (IF:4.206)
63. Chen, C.-L., Tetri, B. A., Huang, S. S., Huang, J. S., (2011) A mechanism by which dietary trans fats cause atherosclerosis. J. Nutritional Biochem., 22(7):649-55 (IF: 4.288). (第一作者)
64. Chen, C.-L., Hou, W.-H., Liu, I-Hua., Hsiao, G., Huang, S. S., Huang, J. S., (2009) Inhibitors of clathrin-dependent endocytosis enhance TGF-β signaling and responses. J. Cell. Sci., 122:1863-1871 (IF: 6.114). (第一作者)
65. Chen, C.-L., Huang, S. S., Huang, J. S., (2008) Cholesterol modulates cellular TGF-β responsiveness by altering TGF-β binding to TGF-β receptors. J. Cell. Physiol., 215: 223-33 (IF: 4.586). (第一作者)
66. Chen, C.-L., Y.-H., Liu., Fliesler, S. J., Han, X., Huang, S. S., Huang, J. S., (2007) Cholesterol suppresses cellular TGF-β responsiveness: implications in atherosclerosis. J. Cell. Sci., 120: 3509-3521 (IF:6.114). (第一作者)
67. Chen, C.-L., Huang, S. S., Huang, J. S. (2006) Cellular heparan sulfate negatively modulates TGF-β1 responsiveness in epithelial cells. J.Biol. Chem., 281, 11506-11514 (IF: 5.328). (第一作者)
68. Ling, T.-Y*., Chen, C.-L.*, Huang, Y.-H., Liu, I.-H., Huang , S.S., and Huang, J. S. (2004)Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J.Biol. Chem., 279, 38736-38748 (IF: 5.328) *contributed equally. (第一作者)
69. Huang, S. S., Leal, S. M., Chen, C.-L., Liu, I.-H., and Huang, J. S. (2004) Identification of insulin receptor substrate proteins as key molecules for the TβR-V/LRP-1-mediated growth inhibitory signaling cascade in epithelial and myeloid cells. FASEB J. 17, 110-117 (IF: 6.401)
70. Huang, S. S., Leal, S. M., Chen, C.-L., Liu, I-H., and Huang,, J. S. (2004) Cellular growth inhibition by TGF-β1 involves IRS proteins. FEBS Letters 565, 117–121. (IF: 3.541).